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Methylene blue is a synthetic dye first created in 1876 by German chemist Heinrich Caro while working for BASF, originally intended for use in the textile industry. Soon after its discovery, scientists realized it had important medical and biological applications, and by the late 19th century it was being used as a staining agent in microscopy, helping advance bacteriology and cell biology. In 1891, Paul Ehrlich demonstrated its medical potential by using it to treat malaria, making methylene bl
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