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What Was Variolation? - Science Through Time
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While Lady Mary Wortley Montagu is renowned for introducing smallpox variolation to England in the 1720s, the systematic development of modern vaccines often occurred in public health laboratories. In the 1930s, bacteriologists Pearl Kendrick and Grace Eldering worked for the Michigan Department of Health. Their critical innovation was culturing the whooping cough (pertussis) bacterium on a medium of human blood, which allowed them to produce an effective vaccine. Facing skepticism and limited f
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While Lady Mary Wortley Montagu is renowned for introducing smallpox variolation to England in the 1720s, the systematic development of modern vaccines often occurred in public health laboratories. In the 1930s, bacteriologists Pearl Kendrick and Grace Eldering worked for the Michigan Department of Health. Their critical innovation was culturing the whooping cough (pertussis) bacterium on a medium of human blood, which allowed them to produce an effective vaccine. Facing skepticism and limited f
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“In Asia, practitioners developed the technique of variolation—the deliberate infection with smallpox. Dried smallpox scabs were blown into the nose of an individual who then contracted a mild form of the disease. Upon recovery, the individual was immune to smallpox. Between 1% to 2% of those variolated died as compared to 30% who died when they contracted the disease naturally. By 1700, variolation had spread to Africa, India and the Ottoman Empire. In contrast to Asians and Africans who inocul
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