Isaacs is the true main antagonist of the Resident Evil film series, having orchestrated the events of the movies though he only plays a direct role in the final movie.

List of Resident Evil characters From left to right: series characters Leon S. Kennedy, Rebecca Chambers, Jill Valentine, Chris Redfield, and Claire Redfield in the animated film Resident Evil: …

Dr. William Birkin (ウィリアム・バーキン Wiriamu Bākin?) was a virologist who worked for Umbrella Pharmaceuticals in the 1970s-1990s.

Dr. James Marcus (ジェーマス・マーカス Jēmasu Mākasu?) was a virologist who led viral weapons research in the 20th century, serving as one of the co-founders of Umbrella Pharmaceuticals and …

Dr. Alexander Roland Isaacs is the main antagonist of the Resident Evil film series. He is the co-founder and supreme leader of the Umbrella Corporation, as well as the true mastermind behind the T-Virus …

Individuals involved in scientific research.

Dr. Victor Gideon (ヴィクター・ギデオン, vikutā gideon?) was a former Umbrella Corporation researcher who participated in the Tyrant Project. Following Umbrella’s bankruptcy in 2003, he …

Doctor Salvador, also known as the Chainsaw Man is a supporting antagonist in Resident Evil 4 and its 2023 remake. He, along with his Giant Chainsaw Man (Super Salvador) form are the most powerful …

Dr. Alexander Isaacs is a fictional character of the Resident Evil film franchise who appeared as the main antagonist in the series. He served as a minor antagonist in Resident Evil: Apocalypse and the …

He is portrayed by Iain Glen, who also portrayed Dr. Alexander Isaacs and his other clone in the series' final instalment Resident Evil: The Final Chapter - as well as Manfred Powell in the 2001 film Lara …