Background Previous natural history studies highlighted a consistent heterogeneity of disability trajectories among ...

Objective Although Wernicke-Korsakoff syndrome (WKS) is a common condition, diagnosis remains difficult. WKS not associated with alcohol is rare and thought to present differently to alcohol-related ...

Apathy is increasingly recognised as a common behavioural syndrome in psychiatric disorders, but it is conceptually ill defined. The aim of this study was to examine the concept of apathy as it is ...

Objective Drug-resistant temporal lobe epilepsy (TLE) often requires thorough investigation to define the epileptogenic zone for surgical treatment. We used simultaneous interictal scalp EEG-fMRI to ...

Background Deep brain stimulation (DBS) is a neurosurgical procedure indicated in patients with advanced Parkinson’s disease (PD). This systematic review and meta-analysis aimed to investigate the ...

4 Department of Neurosurgery, Royal Prince Alfred Hospital, Camperdown, Sidney, Australia Correspondence to: Dr Nicholas Higgins Department of Radiology, Box 219, Addenbrooke’s Hospital, Hills Road, ...

Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, the Netherlands, and Julius Centre for Health Sciences and Primary Care, University ...

Objective: To determine the pattern of motor neurone loss in amyotrophic lateral sclerosis (ALS). In particular, to determine whether there is a gradual life long presymptomatic motor neurone loss or, ...

a Department of Neurology, Leiden University Medical Centre, The Netherlands, b Department of Medical Statistics, Leiden University Medical Centre, The Netherlands Professor RAC Roos, Department of ...

The increasing complexity of the genetic landscape in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) presents a significant resource and physician training challenge. At least ...

Introduction Zonisamide is a pleiotropic, second generation anti-seizure medication (ASM) used in the treatment of focal and generalised epilepsy. It is generally well tolerated; however metabolic ...

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