Seth Rogen, Stephen Graham, Noah Wyle, Katherina LaNasa and more reacted to their Emmy nominations, which were announced Tuesday morning.

Of course, Wyle is no stranger to garnering awards buzz, having earned 5 noms for Outstanding Supporting Actor in a Drama for his excellent work as up-and-coming surgeon Dr. John Carter on ER. On his newest series,

In a statement shared with PEOPLE, Wyle, 54, said of the nominations, including one for outstanding lead actor in a drama series, "I’m humbled and grateful"