The Sporting News is tracking live scoring updates and highlights for 49ers vs. Colts on "Monday Night Football." Follow for ...

Get the best 49ers vs. Colts predictions and odds ahead of Week 16 Monday Night Football on December 22, 2025. Take the Over.

Follow live coverage as Indianapolis attempts to salvage its playoff hopes, hosting San Francisco on "Monday Night Football" ...

Now, the model has analyzed Colts vs. 49ers on 'Monday Night Football' and locked in three confident best bets for an NFL SGP ...

The Colts' playoff chances have taken a nosedive along with their record of late: they're on a four-game losing streak after ...

Caesars Sportsbook pioneered live streaming NFL games in December 2022 by launching its "Watch & Bet" feature for both ...

Breaking down the best wide receiver targets for the 49ers vs. Colts DraftKings MNF Showdown slate, including usage trends, ...

Here are three things to watch for and a prediction for the Indianapolis Colts vs. 49ers Monday Night Football game.

Philip Rivers starts again when he takes on the ferocious 49ers on "Monday Night Football." Here's TV channel, odds and more for Week 16.

The Colts host the 49ers on tonight’s edition of Monday Night Football. The 49ers/Colts game begins at 8:15 p.m. ET on ESPN. Nope. But the Manning boys will return to ESPN2 for the Monday night ...

Week 16 wraps up with one playoff team and one playoff hopeful. The Niners are rising; the Colts are desperate.