Alkanediols such as 1,6-hexanediol disrupt many phase-separated condensates in cellula and in vitro, but how molecular interactions are perturbed by these compounds remains unclear. This study uses ...

Multi-modal data integration of single-nuclei RNA and ATAC sequencing with spatial transcriptomics, provides new molecular insights into gene regulatory networks driving cell state transitions in ...

Proteomics profiling of a pre-metastatic colorectal cancer cohort identifies four proteomics-based subtypes and highlights ...

I was at a cancer meeting in Brisbane when the question about the culture of a community occurred to me. The meeting was well ...

Top-down proteomics: Intact proteins are ionized and analyzed directly, allowing for the study of proteoforms and ...

The role of centrosomal tubulin glutamylation has remained elusive for decades. Here, a new tool enables precise ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Protein Kinase A (PKA) is regulated spatially ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Type 2 diabetes (T2D) presents a global health ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Primary cilia are solitary organelles formed ...

This month's cover highlights the article AAV-mediated expression of proneural factors stimulates neurogenesis from adult Müller glia in vivo by Marina Pavlou, Thomas A. Reh and colleagues. Injuring ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Neurotoxins derived from animal venoms are ...