BMJ

FOXP3 expression in blood, synovial fluid and synovial tissue during inflammatory arthritis and intra-articular corticosteroid treatment

Objective: To analyse the distribution of FOXP3+CD25+CD4+ regulatory T cells (Treg) in peripheral blood, synovial fluid and tissue of patients with rheumatic disease during relapse and after local ...
BMJ

Thickness of human articular cartilage in joints of the lower limb

OBJECTIVES (a) To determine the topographical variations in cartilage thickness over the entire surfaces of cadaveric lower limb joints, and (b) to examine the correlations between: cartilage ...
BMJ

The cathelicidins LL-37 and rCRAMP are associated with pathogenic events of arthritis in humans and rats

3 Rheumatology Unit, Department of Medicine at the Karolinska University Hospital Solna, Sweden 4 Division of Rheumatology, Department of Internal Medicine 3, Medical University of Vienna, Vienna, ...
BMJ

Sclerosing skin disorders in association with multiple sclerosis. Coincidence, underlying autoimmune pathology or interferon induced?

Ulrich A Walker, Department of Rheumatology, Felix Platter Spital, Burgfelderstrasse 101, Basel 4012, Switzerland; ulrich.walker{at}fps-basel.ch Objectives: To describe and analyse the manifestation ...
BMJ

Combination therapy with sulfasalazine and methotrexate is more effective than either drug alone in patients with rheumatoid arthritis with a suboptimal response to ...

Background: Optimal use of disease-modifying antirheumatic drugs (DMARDs) in rheumatoid arthritis is vital if progression of disease is to be reduced. Methotrexate (MTX) and sulfasalazine (SASP) are ...
BMJ

Etanercept therapy in rheumatoid arthritis and the risk of malignancies: a systematic review and individual patient data meta-analysis of randomised controlled trials

Division of Rheumatology and Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA Purpose: Tumour necrosis factor (TNF) plays an important role in inflammation ...
BMJ

Moderate vitamin D deficiency is associated with changes in knee and hip pain in older adults: a 5-year longitudinal study

Background Vitamin D is important for bone, cartilage and muscle function but there are few studies on its association with joint pain. Objective To investigate whether serum vitamin D predicts change ...
BMJ

Anti-adalimumab antibodies and adalimumab concentrations in psoriatic arthritis; an association with disease activity at 28 and 52 weeks of follow-up

Objectives To investigate the relationship between antidrug antibodies (ADA), adalimumab concentrations and clinical response in patients with psoriatic arthritis (PsA) during 52 weeks of follow-up.
BMJ

Defining minimal disease activity in psoriatic arthritis: a proposed objective target for treatment

Objective: To create minimal disease activity (MDA) criteria for psoriatic arthritis (PsA). With recent therapeutic advances, this is now a goal for treatment and may represent a measure to compare ...
BMJ

Minimal clinically important improvement/difference (MCII/MCID) and patient acceptable symptom state (PASS): what do these concepts mean?

National Resource Centre for Rehabilitation in Rheumatology, Departmentt of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway Tore K Kvien, Department of Rheumatology, Diakonhjemmet Hospital, Box 23 ...
BMJ

Impact of smoking as a risk factor for developing rheumatoid arthritis: a meta-analysis of observational studies

Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Kobe, Japan Method: Data sources were observational studies that examined the association between smoking ...
BMJ

Defining conditions where long-term glucocorticoid treatment has an acceptably low level of harm to facilitate implementation of existing recommendations: viewpoints from an ...

3 Amsterdam Rheumatology& Immunology Center, VU University Medical Center, Amsterdam, the Netherlands 4 Medical Humanities, VU Medical Centre, Amsterdam, the Netherlands ...