The San Francisco 49ers offense is cruising and they were dominant in a win over the Indianapolis Colts. Here are the ...

With that latest touchdown from San Francisco, the Colts have now conceded more points (41) tonight than they have allowed in any game all season. The 49ers have piled up 433 yards of offense so far.

Philip Rivers starts again when he takes on the ferocious 49ers on "Monday Night Football." Here's score, highlights, stats ...

Get the best 49ers vs. Colts predictions and odds ahead of Week 16 Monday Night Football on December 22, 2025. Take the Over.

The Sporting News is tracking live scoring updates and highlights for 49ers vs. Colts on "Monday Night Football." Follow for complete results from the NFL Week 16 prime-time game.

Now, the model has analyzed Colts vs. 49ers on 'Monday Night Football' and locked in three confident best bets for an NFL SGP ...

Here are three things to watch for and a prediction for the Indianapolis Colts vs. 49ers Monday Night Football game.

The Indianapolis Colts host the San Francisco 49ers in NFL Week 16 action on 'Monday Night Football': Live score updates, highlights, where to watch.

The Colts host the 49ers on tonight’s edition of Monday Night Football. The 49ers/Colts game begins at 8:15 p.m. ET on ESPN. Nope. But the Manning boys will return to ESPN2 for the Monday night ...

Eddy Pineiro redeemed himself in the 49ers' MNF matchup against the Indianapolis Colts with a textbook field goal after a ...