St. Frances football star and Maryland signee Zion Elee is The Baltimore Sun’s 2025 All-Metro Defensive Player of the Year.

The Seahawks and Lions lead the clear D/ST starts, but the Packers and Falcons headline the streamers to watch. Here’s how to set your fantasy defense in Week 12.

Defenses will likely have a significant say in who wins fantasy football championships, so be sure not to overlook the position. Use our updated Week 16 fantasy football defense (DST) rankings for 2025 to pinpoint the best team defense for your lineups.