The Jaguars have won six in a row, mostly against the dregs of the league, but proved themselves legit by taking down the No.

Brock Purdy throws a career-high five touchdown passes as San Francisco beat Indianapolis 48-27 to keep their NFC West title ...

Jauan Jennings caught Brock Purdy’s fourth touchdown pass of the night as the 49ers quarterback became the first San Francisco passer to throw seven touchdowns over a course of two weeks since Jeff ...

The San Francisco 49ers are going to make the playoffs, but there are not many people who believe that they are legitimate ...

San Francisco 49ers linebacker Dee Winters made a huge play in the fourth quarter to finish off the Indianapolis Colts.

Quarterback Philip Rivers came out of retirement to lead the Indianapolis Colts to the playoffs. Two games into his comeback, their postseason hopes barely exist.

The San Francisco 49ers have beaten the Indianapolis Colts 48-27 on “Monday Night Football” behind Brock Purdy ’s career-high five touchdown passes. Christian McCaffrey racked up 146 total scrimmage ...

Colts quarterback Philip Rivers had one of the best performances by a 44-year-old in NFL history, and the defense ruined it ...

The San Francisco 49ers outlasted the Indianapolis Colts 48-27 on the road to close out Week 16 on Monday Night Football, ...

The Week 16 edition of "Monday Night Football" between the Indianapolis Colts (8-7) and the San Francisco 49ers (11-4) will ...

The Indianapolis Colts lose to the San Francisco 49ers in NFL Week 16 action on 'Monday Night Football': Score updates, highlights ...

Brock Purdy and the San Francisco 49ers earned a statement 48–27 road win over Philip Rivers and the Indianapolis Colts on Monday Night Football, as both quarterbacks put on an entertaining aerial ...