Brock Purdy lit up MNF for the 49ers against the Colts, throwing five TDs and making history with a mark not seen in 35 years ...

Here's what's known about Indianapolis' plans for its 44-year-old quarterback, and why it may make sense to stop playing Rivers.

San Francisco 49ers linebacker Dee Winters made a huge play in the fourth quarter to finish off the Indianapolis Colts.

San Francisco 49ers defensive coordinator Robert Saleh, offensive coordinator Klay Kubiak, and quarterback Brock Purdy spoke to reporters after Friday's practice as the team gets ready for its Week 16 ...

The San Francisco 49ers have beaten the Indianapolis Colts 48-27 on “Monday Night Football” behind Brock Purdy ’s career-high five touchdown passes. Christian McCaffrey racked up 146 total scrimmage ...

Philip Rivers starts again when he takes on the ferocious 49ers on "Monday Night Football." Here's score, highlights, stats and more for Colts-49ers.

The Jaguars have everything in front of them over the next two weeks to allow them to take full advantage of the opportunity ...

Indianapolis Colts quarterback Philip Rivers made NFL fans smile on Monday night with a great showing in the first half ...

In Sporting News' Week 17 picks against the spread, Philadelphia wins at Buffalo, Pittsburgh goes well into Cleveland and the 49ers win in Chicago.

The Buffalo Bills, Jacksonville Jaguars and Los Angeles Chargers qualified for the AFC playoffs with the Indianapolis Colts’ ...

The San Francisco 49ers head to Indianapolis for their final road trip of the regular season, taking on the Indianapolis Colts at Lucas Oil Stadium on ESPN's Monday Night Football. This matchup marks ...

Brock Purdy may be angling to become Santa's backup during the holiday season. The San Francisco 49ers quarterback once again helped organize a Christmas ...