There are highs and lows every week in college football. The winners and losers for Week 4 start with Southern California's loss to Michigan.

No. 18 Michigan inflicted a pair of significant blows in the first half against No. 11 USC on Saturday, taking a 14-3 lead into the break behind stingy defense and explosiveness in its run game. Kalel Mullings busted a 53-yard touchdown run on the Wolverines' third possession to open the scoring after the teams traded early punts.

In Week 3 against Arkansas State, star tight end Colston Loveland left the game early with an apparent shoulder injury and looks to be a game-time decision. The Wolverines were shorthanded last week with Jaden Mangham, Jordan Marshall, and Tyler Morris out last week, and some other notable players also unable to go.