The protein is implicated in a wide swath of cancers, but harnessing it for drug R&D is still a major scientific challenge.

Researchers in the lab of Michael Sigal at the Max Delbrück Center and Charité – Universitätsmedizin Berlin have elucidated the role of the p53 gene in ulcerative colitis. The study, published in ...

Trim24 regulates a subset of p53 target genes. a, Number and overlap of genes that change upon p53 activation compared with uninduced cells and upon Trim24 degradation in p53-active conditions. b, p53 ...

The results of research headed by a team in the lab of Michael Sigal, MD, at the Max Delbrück Center and Charité—Universitätsmedizin Berlin, have shed new light on the role of the p53 tumor suppressor ...

Anti-tumor effects of molecular glue BC. (a) Representative images of tumors in different treatment groups after 28 days. (b) Quantifications of anti-tumor activity of compound BC in the xenograft. (c ...