Researchers have created the first blueprint of the human spliceosome, the most complex and intricate molecular machine in human biology. The vast majority of human genes -- more than nine in ten -- ...

Johns Hopkins researchers have developed a powerful new AI tool called Splam that can identify where splicing occurs in genes—an advance that could help scientists analyze genetic data with greater ...

Alternative splicing is a genetic process where different segments of genes are removed, and the remaining pieces are joined together during transcription to messenger RNA (mRNA). This mechanism ...

This article was review by Thomas Cooper, MD from Baylor College of Medicine. Stay up to date on the latest science with Brush Up Summaries. Despite its significance, alternative splicing’s global ...

Researchers have identified 813 possible cancer driver genes, significantly expanding the list of potential therapeutic targets for treating the disease. The genes help cancer cells grow through a non ...

In an important new study, Chinese researchers have discovered the previously unrecognized role of alternative splicing of the DOC2A gene in schizophrenia. The research was conducted by scientists led ...

Type-II diabetes is a chronic disease caused by insulin resistance due to pancreatic β-cell dysfunction. Mutations in a single gene, HNF1A, which codes for the transcription factor hepatocyte nuclear ...

Although the participation of spliceosomes is almost always required for intron removal, a few types of genes have self-splicing RNA introns.