A new study in Nature has mapped, at atomic resolution, how the enzyme DICER slices precursor microRNAs at exactly the right ...

A research team from The Hong Kong University of Science and Technology (HKUST) has made an advance in understanding the molecular machinery of RNA silencing. The team uncovered how the human enzyme ...

Scientists have gotten their first detailed look at the molecular structure of an enzyme that Nature has been using for eons to help silence unwanted genetic messages. A team of researchers with ...

Cells use RNA as a versatile tool to regulate the activity of their genes. Small snippets of RNA can fine-tune how much protein is produced from various genes; some small RNAs can shut genes off ...

The first crystal structure of Dicer, an enzyme that initiates RNA interference (RNAi), suggests how it works. RNAi is a process in which short RNA molecules recognize messenger RNAs and mark them for ...

RNase III proteins have central roles in RNA silencing by processing double-stranded (ds)RNA precursors into small RNA duplexes 1. Drosha cleaves a primary precursor of miRNA (pri-miRNA) to release a ...