The activity of alcohol dehydrogenase, an enzyme present principally in liver tissue, was repetitively determined in the serums of 266 patients with hepatic and nonhepatic diseases. The enzyme was ...

Background and Aim:Progressive familial intrahepatic cholestasis type 2 (PFIC2) results from genetic defects of the hepatobiliary bile salt export pump (BSEP, ABCB11) at chromosome 2q24. Patients with ...

In summary, the molecular events in estrogen-induced cholestasis affect many transport systems in the basolateral and canalicular membrane, whereby the uptake side seems to be mainly affected at the ...

A recent study published in Frontiers in Medicine evaluated the effects of coronavirus disease 2019 (COVID-19) quarantine on outcomes in individuals with intrahepatic cholestasis of pregnancy (ICP).

Credit: Mirum Pharmaceuticals. The approval was based on data from the phase 3 MARCH-PFIC trial. The Food and Drug Administration (FDA) has approved Livmarli ® (maralixibat) for the treatment of ...

Despite these recent advancements in medical management, there are still some important clinical issues to refine. The first is the diagnosis of ICP. Women with cholestasis present with pruritis, ...

Please provide your email address to receive an email when new articles are posted on . In a randomized, double-blind, placebo-controlled trial, researchers analyzed a pooled analysis of 77 patients ...

Late in my pregnancy, my feet and hands started itching, and nothing gave me relief. I recognized it as intrahepatic cholestasis, which can increase the risk of stillbirth. I got a prescription to ...

She had been previously admitted to another facility with similar complaints. After extensive workup, which ruled out acute and chronic liver disease, as well as mechanical obstruction of the biliary ...