Activation of the phosphatase calcineurin in intestinal epithelial cells (IECs) promotes intestinal tumour development, according to new research. Dysbiosis, commonly found early in colorectal cancer ...

Pimecrolimus and tacrolimus, 2 topical calcineurin inhibitors for the treatment of atopic dermatitis (AD), were not shown to increase the risk of cancer based on moderate-certainty evidence from a ...

Calcineurin is a calcium-calmodulin-activated serine/threonine phosphatase that orchestrates a myriad of cellular processes by dephosphorylating key substrates, most notably the nuclear factor of ...

Topical calcineurin inhibitors (TCIs) are a type of treatment that alters your immune system. You can use TCIs for atopic eczema. These therapies are “topical,” which means you put them on your skin. ...

Topical calcineurin inhibitors (TCIs) for atopic dermatitis, a.k.a. eczema, did not seem to up the long-term risk for developing skin cancer, according to a manufacturer-sponsored study. Among nearly ...

Please provide your email address to receive an email when new articles are posted on . LOUISVILLE, Ky. — Researchers showed with moderate certainty that topical calcineurin inhibitors did not ...

Excess α-synuclein kills neurons, and part of the reason may well be that the protein causes the cells to overdose on calcium, which hyperactivates the phosphatase calcineurin. In the August 13 ...

Am J Health Syst Pharm. 2006;63(23):2340-2348. MDR1 (ABCB1) T-129C, C1236T, G2677(T,A), C3435T No difference observed for cyclosporine and any CYP3A5 polymorphism Wild-type carriers of MDR1 (ABCB1) ...

Atopic dermatitis (AD) is a type of eczema, a condition that makes skin dry, red, and itchy. There are many ways to tame its symptoms, from creams that control itching to light therapy. But about half ...

Please provide your email address to receive an email when new articles are posted on . Calcineurin inhibitor therapy for orthotopic liver transplantation — at both low and standard doses — increased ...

Credit: Getty Images In a meta-analysis of 16 randomized clinical trials, calcineurin inhibitors showed better efficacy than standard of care lupus nephritis induction over the short term. Calcineurin ...