At the time, the Oscar winner had to turn down the leading role as he was busy leading James Cameron’s ‘Titanic.’

When asked by Anderson — who interviewed DiCaprio for the outlet while promoting their upcoming film, One Battle After Another — if he has any regrets over his 35+ years in the entertainment industry, the actor doesn't hold back his truth "even though you're here."

Leonardo DiCaprio says the biggest regret of his acting career is turning down Paul Thomas Anderson's offer to star as the lead in 'Boogie Nights.'